Sodium Hydroxide → HCID 22277797, compound

HRID 2055326Notes

Reaction equation

HRID 2055326 reaction equation
[CH2:1]([CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([O:16]CC)=[O:15])[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[C:14]([CH2:13][N:10]1[CH2:11][CH2:12][CH:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]1=[O:19])([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22277832HCID 22277832, compound

Product 1

HCID 22277797HCID 22277797, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-benzyl-1-(ethoxycarbonylmethyl)-2-pyrrolidinone (Method 5; 0.70 g, 2.68 mmol) and 2 M NaOH (4 ml) was stirred in ethanol (10 ml) for 24 hours. The mixture was evaporated in vacuo and the residue acidified. The product was collected by filtration and dried under high vacuum. NMR (90 MHz, CDCl3) 7.9 (s, 1H), 7.2 (in, 5H), 4.1 (d, 1H), 3.3 (m, 2H), 2.25 (m, 2H), 2.3-1.6 (m, 4H).

Workup

  1. customThe mixture was evaporated in vacuo
  2. filtrationThe product was collected by filtration
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-732d76a6c90448c584bd778913523a7a
Source dataset
uspto-grants-2008_02
Patent number
US07332492B2

Reaction notes

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