tert-butyl N-(pyrrolidin-3-yl)carbamate → HCID 86596620, compound

HRID 2055427Notes

Reaction equation

HRID 2055427 reaction equation
[NH:1]1[CH2:5][CH2:4][CH:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:2]1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](I)=[CH:17][N:16]=1>>[Cl:14][C:15]1[N:16]=[CH:17][C:18]([N:1]2[CH2:5][CH2:4][CH:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:10])([CH3:12])[CH3:11])[CH2:2]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 43971762-Chloro-5-iodopyridine

Product 1

HCID 86596620HCID 86596620, compoundYield 48%

Procedure

tert-Butyl 3-pyrrolidinylcarbamate (0.377 g, 2.03 mmol; TCI) and 2-chloro-5-iodopyridine (0.484 g, 2.03 mmol; Aldrich) were processed according to the procedure of Example 1A to provide the title compound (0.29 g, 48%). MS (CI/NH3) m/z 298/300 (M+H)+.

Sources & evidence

ORD record
ord-72eff20ff4794e0eadc5d5b1e272b136
Source dataset
uspto-grants-2008_02
Patent number
US07332504B2

Reaction notes

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