4-(N-Boc-amino)piperidine → HCID 53486065, compound

HRID 2055429Notes

Reaction equation

HRID 2055429 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19](I)=[CH:18][N:17]=1>>[Cl:15][C:16]1[N:17]=[CH:18][C:19]([N:1]2[CH2:2][CH2:3][CH:4]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12])[CH2:5][CH2:6]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 43971762-Chloro-5-iodopyridine

Product 1

HCID 53486065HCID 53486065, compoundYield 43.2%

Procedure

tert-butyl 4-piperidinylcarbamate (0.30 g, 1.50 mmol; Astatech) and 2-chloro-5-iodopyridine (0.287 g, 1.50 mmol; Aldrich) were processed according to the procedure of Example 1A to provide the title compound as a yellow oil (0.202 g, 43%). (DCI/NH3) m/z 312 (M+H)+.

Sources & evidence

ORD record
ord-2ccf345ead134ff0858b27aec36f0439
Source dataset
uspto-grants-2008_02
Patent number
US07332504B2

Reaction notes

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