2-Chloro-1-(3-fluorophenyl)ethan-1-one → HCID 57978130, compound

HRID 2055479Notes

Reaction equation

HRID 2055479 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([O:26][C:27](=[O:28])[C:4]=2[CH:3]=1)[CH2:13][CH2:12][N:11]([C:14]([C:16]1[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[NH:18][CH:17]=1)=[O:15])[CH2:10][CH2:9]3.Cl[CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=1)=[O:32]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([O:26][C:27](=[O:28])[C:4]=2[CH:3]=1)[CH2:9][CH2:10][N:11]([C:14]([C:16]1[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[N:18]([CH2:30][C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=2)=[O:32])[CH:17]=1)=[O:15])[CH2:12][CH2:13]3

Participants

3

Reactant 2

HCID 222488382-Chloro-1-(3-fluorophenyl)ethan-1-oneHCID 596576195-bromo-1'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

Product 1

HCID 57978130HCID 57978130, compound

Procedure

Following the general procedure III as described above, the alkylation of 5-bromo-1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one with commercially available 2-chloro-1-(3-fluoro-phenyl)-ethanone gave the title compound.

Sources & evidence

ORD record
ord-423df0dac86346ee989af81558786fd3
Source dataset
uspto-grants-2008_02
Patent number
US07332501B2

Reaction notes

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