Formamide → HCID 135553012, compound

HRID 2055560Notes

Reaction equation

HRID 2055560 reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]

Participants

3

Reactant 2

HCID 713FormamideHCID 117799312-Amino-3-bromo-5-chlorobenzoic acid

Product 1

HCID 135553012HCID 135553012, compound

Procedure

8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+

Workup

  1. temperatureat reflux overnight
  2. temperatureThe mixture was cooled
  3. customquenched with water
  4. customThe solid that formed
  5. washwas washed with acetonitrile, 6.7 g crude (65%)

Sources & evidence

ORD record
ord-4dd82de2a8234fc5b58672625743b906
Source dataset
uspto-grants-2008_02
Patent number
US07332506B2

Reaction notes

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