Pyridine → 3,5-didecoxybenzyl Chloride

Temperature

0 °C

Dry dichloromethane (5 mL), DMF (3.04 mL, 39.2 mmol), and a magnetic stir bar were placed into a 250 mL RBF and sealed with a rubber septum. N2 inlet and outlet needles were inserted into the septum. The flask was then cooled to 0° C. in an ice bath. Thionyl chloride (2.86 mL, 39.2 mmol) was added to the RBF via a syringe. The RBF was placed into an ice bath and cooled to 0° C. 3,5-didecoxybenzyl alcohol (15.0 g, 35.7 mmol) was dissolved in a solution of dichloromethane (60 mL) containing pyridine (2.88 mL, 35.7 mmol). This solution was then drawn into a syringe and added cautiously to RBF over 20 minutes. The solution gradually changed from a transparent yellow color to an opaque yellow color. Dichloromethane was used to rinse the beaker which was used to dissolve 3,5-didecoxybenzyl alcohol and then added to the RBF. The RBF was removed from the ice bath and allowed to stir overnight. The solution was then concentrated using a rotary evaporation. A solution of 50/50 ether/hexanes (100 mL) was added to the RBF, changing the solution from deep yellow to opaque white. The liquid was decanted off leaving behind any solid. The RBF was rinsed in this manner 2 more times, saving the decanted liquid. The decanted liquid was run through a silica gel baseline filtration apparatus. Filtrate was then concentrated using rotary evaporation. A compound solidified after approximately 2 hours under a high vacuum. There was a 14.8 g yield or a 94.5% yield of the derivative. The NMR characterization data for this derivative is as follows. 1NMR (300 MHz, CDCl3): 0.88 (t, J=6.6, 6H, CH2CH3), 1.27-1.43 (m, 28H, CH2(CH2)7), 1.76 (p, J=6.6, 4H, OCH2CH2), 3.92 (t, J=6.6, 4H, OCH2), 4.50 (s, 2H, ArCH2Cl), 6.39 (t, J=2.2, 1H, ArH), 6.50 (d, J=2.5, 2H, ArH). 13C NMR (75 MHZ, CDCl3): 14.23, 22.78, 26.12, 29.30, 29.42, 29.47, 29.70, 32.00, 46.56, 68.18, 101.332, 106.97, 139.38, 160.52.

1. customsealed with a rubber septum
2. customN2 inlet and outlet needles were inserted into the septum
3. customThe RBF was placed into an ice bath
4. temperaturecooled to 0° C
5. customThis solution was then drawn into a syringe
6. additionadded cautiously
7. washto rinse the beaker which
8. dissolutionto dissolve 3,5-didecoxybenzyl alcohol
9. additionadded to the RBF
10. customThe RBF was removed from the ice bath
11. concentrationThe solution was then concentrated
12. customa rotary evaporation
13. additionA solution of 50/50 ether/hexanes (100 mL) was added to the RBF
14. customThe liquid was decanted off
15. customleaving behind any solid
16. washThe RBF was rinsed in this manner 2 more times
17. filtrationThe decanted liquid was run through a silica gel baseline filtration apparatus
18. concentrationFiltrate was then concentrated
19. customevaporation
20. waitA compound solidified after approximately 2 hours under a high vacuum
21. customyield

ORD record

ord-54324171d6d7436495fa29a03f23ba05

Source dataset

uspto-grants-2008_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07332529B2