Veratrole → (2,3-Dimethoxyphenyl)(4-pyridinyl)methanol

HRID 2055841Notes

Reaction equation

HRID 2055841 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[O:8])=[CH:3][CH:2]=1.[C:9]1([O:17][CH3:18])[C:10](=[CH:13][CH:14]=[CH:15][CH:16]=1)[O:11][CH3:12]>>[OH:8][CH:7]([C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)[C:16]1[CH:15]=[CH:14][CH:13]=[C:10]([O:11][CH3:12])[C:9]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 7043VeratroleHCID 133894-Pyridinecarboxaldehyde

Product 1

HCID 314742(2,3-Dimethoxyphenyl)(4-pyridinyl)methanol

Procedure

In Scheme F, step d, 4-pyridinecarboxaldehyde (9) is reacted with lithiated veratrole to give 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]pyridine (10).

Sources & evidence

ORD record
ord-ae5588eabcd84d4cb31f0e39323de5a0
Source dataset
uspto-grants-2008_02
Patent number
US07332607B2

Reaction notes

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