Triethylamine → HCID 10450766, compound

HRID 2055901Notes

Reaction equation

HRID 2055901 reaction equation
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7])[CH3:2].[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([N+:24]([O-:26])=[O:25])=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1.C(N(CC)CC)C>ClCCl>[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([N+:24]([O-:26])=[O:25])=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:19]=1)=[O:7])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 949554-Nitro-3-(trifluoromethyl)anilineHCID 30163972-Ethoxybenzoyl chloride

Product 1

HCID 10450766HCID 10450766, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-ethoxy--benzoyl chloride was condensed with 5-Amino-2-nitrobenzotrifluoride in dichloromethane in presence of triethylamine as acid scavenger to yield 2-Ethoxy-N-(4-nitro-3-trifluromethyl-phenyl)-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

Sources & evidence

ORD record
ord-eb345e951eab4874b4da5d0acbdea034
Source dataset
uspto-grants-2008_02
Patent number
US07332629B2

Reaction notes

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