Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 6-chloro-2-(trifluoromethyl)-7H-purine | HCID 6053911 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 69078811 | HCID 69078811 | 49% |
Reaction Steps
6-Chloro-2-trifluoromethylpurine (1.10 g, 5.0 mmol) in 25 ml of methanol was treated with 1.35 g (25 mmol) of sodium methoxide at 80° C. for 60 hours. Water (50 ml) and ethyl acetate (50 ml) were added after the reaction mixture was cooled to 20° C. The organic layer was separated and concentrated. Chromatography gave 535 mg (49%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07335654B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-56e80db4a9ae47488df0c071988da774 |
|---|
| Source note | uspto-grants-2008_02 |
|---|
