Water → HCID 69078811, compound

HRID 2056246Notes

Reaction equation

HRID 2056246 reaction equation
Cl[C:2]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2.C[O-].[Na+].O.[C:19](OCC)(=[O:21])C>CO>[CH3:19][O:21][C:2]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[C:7]2[C:3]=1[NH:4][CH:5]=[N:6]2

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 60539116-chloro-2-(trifluoromethyl)-7H-purineHCID 10942334Sodium Methoxide

Product 1

HCID 69078811HCID 69078811, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

6-Chloro-2-trifluoromethylpurine (1.10 g, 5.0 mmol) in 25 ml of methanol was treated with 1.35 g (25 mmol) of sodium methoxide at 80° C. for 60 hours. Water (50 ml) and ethyl acetate (50 ml) were added after the reaction mixture was cooled to 20° C. The organic layer was separated and concentrated. Chromatography gave 535 mg (49%) of the title compound.

Workup

  1. customThe organic layer was separated
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-56e80db4a9ae47488df0c071988da774
Source dataset
uspto-grants-2008_02
Patent number
US07335654B2

Reaction notes

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