4-(Trifluoromethyl)benzaldehyde → 4-Iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazole

HRID 2056397Notes

Reaction equation

HRID 2056397 reaction equation
[I:1][CH2:2][C:3]1[N:4]=C(C2C=CC(C)=CC=2)O[C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:39])([F:38])[C:30]1[CH:37]=[CH:36][C:33]([CH:34]=[O:35])=[CH:32][CH:31]=1>>[I:1][CH2:2][C:3]1[N:4]=[C:34]([C:33]2[CH:36]=[CH:37][C:30]([C:29]([F:38])([F:39])[F:28])=[CH:31][CH:32]=2)[O:35][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 574345144-Iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, diacetylmonoxime and 4-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazole.

Sources & evidence

ORD record
ord-aaaecb28ef5447c7a667b1df15fc3d71
Source dataset
uspto-grants-2008_02
Patent number
US07335671B2

Reaction notes

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