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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2056397Generated: October 27, 2026

4-(Trifluoromethyl)benzaldehyde → 4-Iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazole

https://huagongshe.com/reaction/2056397

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzaldehydeHCID 67996—
Reactant2,3-Butanedione monoximeHCID 6409633—
Reactant4-Iodomethyl-5-phenyl-2-p-tolyloxazoleHCID 57434504—
Product4-Iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazoleHCID 57434514—

Reaction Steps

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyl-oxazole, diacetylmonoxime and 4-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(4-trifluoromethylphenyl)oxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07335671B2
Source datasetuspto-grants-2008_02
ORD IDord-aaaecb28ef5447c7a667b1df15fc3d71
Source noteuspto-grants-2008_02