反应详情

To a solution of 6-chloropyridazine-3-carboxylic acid (2-cyclobutylethyl)-amide (1.2 g, 5.00 mmol) in acetonitrile (40 mL) was added piperazine (1.29 g, 15.00 mmol). The reaction mixture was heated to reflux overnight. The mixture was evaporated and the solid residue was taken in ethyl acetate (100 mL) and water (100 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (2×100 mL). The combined ethyl acetates were dried over Na2SO4 and concentrated in vacuo to give the title compound as yellow solid (1.14 g, 78.4% yield).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux overnight
3. customThe mixture was evaporated
4. customThe organic layer was separated
5. extractionthe aqueous layer was extracted with ethyl acetate (2×100 mL)
6. dry with materialThe combined ethyl acetates were dried over Na2SO4
7. concentrationconcentrated in vacuo