HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4,4-Trifluoro-but-2-enoic acid → HCID 67012040, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4,4-Trifluoro-but-2-enoic acid | HCID 2782431 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | HCID 67012040 | HCID 67012040 | — |
Reaction Steps
Following the procedure of Example 9, making variations only as required to use 4,4,4-trifluorobut-2-enoic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (19.6% yield). 1H NMR (500 MHz, CDCl3) δ 8.09, 8.00, 7.00, 6.81, 3.96-3.88, 3.78, 3.57, 1.53, 0.76, 0.48, 0.10. MS (ES+) m/z 398 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335658B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-d26b3bc99caa4c7aa8b20c23090edc70 |
| Source note | uspto-grants-2008_02 |