Trifluoroacetic acid methylene chloride → HCID 58612064, compound

HRID 2056711Notes

Reaction equation

HRID 2056711 reaction equation
[NH2:1][C:2]1[C:3](=[O:44])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([NH:29][CH2:30][CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][N:32]3[C:37](OC(C)(C)C)=O)[N:14]=1)[CH:8]=[CH:7][CH:6]=2.F[C:46](F)(F)[C:47](O)=O.[CH2:52](Cl)Cl>>[NH2:1][C:2]1[C:3](=[O:44])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([NH:29][CH2:30][CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][N:32]3[CH2:37][CH:47]3[CH2:46][CH2:52]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 58612032HCID 58612032, compound

Product 1

HCID 58612064HCID 58612064, compound

Procedure

The reaction of tert-butyl 2-((4-(3-amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate (Example 133) with 1:1 mixture of trifluoroacetic acid/DCM under the conditions of Example 35 afforded the title compound as an amorphous solid, which was used in the next step without additional purification. MS (ESI, pos. ion) m/z: 512 (M+1).

Sources & evidence

ORD record
ord-1d2830ba525f418ca48b09d6227ad346
Source dataset
uspto-grants-2008_02
Patent number
US07335672B2

Reaction notes

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