Piperazine → HCID 11562108, compound

HRID 2056712Notes

Reaction equation

[NH2:1][C:2]1[C:3](=[O:30])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15](Cl)[N:14]=1)[CH:8]=[CH:7][CH:6]=2.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[NH2:1][C:2]1[C:3](=[O:30])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([N:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

Reactant 2

HCID 4837Piperazine

HCID 58612074HCID 58612074, compound

Product 1

HCID 11562108HCID 11562108, compound

Procedure

The reaction of 3-amino-5-(2-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one (180 mg, 1.0 mmol, Example 106(a)) with piperazine (71 mg, 2.0 mmol, Aldrich) under the conditions of Example 34 afforded the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 484 (M+1).

Sources & evidence

ORD record: ord-93bd0bb974d44471b3f3044c93ee2c9e
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335672B2

Reaction notes

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