Isobutyraldehyde → HCID 11685274, compound

HRID 2056714Notes

Reaction equation

[NH2:1][C:2]1[C:3](=[O:35])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2.[CH:36](=O)[CH:37]([CH3:39])[CH3:38]>>[NH2:1][C:2]1[C:3](=[O:35])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[N:16]=[C:15]([N:29]3[CH2:34][CH2:33][N:32]([CH2:36][CH:37]([CH3:39])[CH3:38])[CH2:31][CH2:30]3)[N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

Reactant 2

HCID 6561Isobutyraldehyde

HCID 11562108HCID 11562108, compound

Product 1

HCID 11685274HCID 11685274, compound

Procedure

The reaction of 3-amino-5-(2-(piperazin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one (97 mg, 0.2 mmol, Example 135) with isobutyraldehyde (43 mg, 0.6 mmol, Aldrich) under the conditions of Example 36 provided the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 540 (M+1).

Sources & evidence

ORD record: ord-9cc947731a0047008b1151eda3c8a65c
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335672B2

Reaction notes

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