反应详情

To a suspension of 2-(6-bromo-3,4-dihydro-1H-2-benzopyran-1-yl)acetic acid (55 g, 203 mmol) in acetonitrile (375 mL) and water (40 mL) was added a solution of (R)-1-(4-methylphenyl)ethylamine (27.45 g, 203 mmol) in acetonitrile (370 mL). The mixture was heated to reflux and the resulting solution cooled to room temperature. A precipitate appeared upon cooling. After stirring for 2 h the salt was filtered off, washed with 95/5 acetonitrile/water (80 mL), and dried in vacuo. The salt was recrystallized in 95/5 acetonitrile/water to give a solid which was suspended in water (390 mL) and treated with 6N HCl (17 mL). After stirring for 1.5 h, filtration, washing, and drying gave the title compound (98% e.e.) as a white solid.

1. temperatureThe mixture was heated
2. temperatureto reflux
3. temperatureupon cooling
4. filtrationwas filtered off
5. washwashed with 95/5 acetonitrile/water (80 mL)
6. customdried in vacuo
7. customThe salt was recrystallized in 95/5 acetonitrile/water
8. customto give a solid which
9. stirringAfter stirring for 1.5 h
10. filtrationfiltration
11. washwashing
12. customdrying