(1S)-1-(2-Hydroxyethyl)-3,4-dihydro-1H-2-benzopyran-6-carboxamide → 1-(2-Hydroxyethyl)-1,3-dihydro-2-benzofuran-5-carboxamide

HRID 2056748Notes

Reaction equation

HRID 2056748 reaction equation
[O:1]([CH2:9][CH2:10][CH:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20]([NH2:22])=[O:21])=[CH:19][C:14]=2[CH2:13][O:12]1)[Si](C(C)(C)C)(C)C.OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1>>[OH:1][CH2:9][CH2:10][CH:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20]([NH2:22])=[O:21])=[CH:19][C:14]=2[CH2:13][O:12]1

Participants

3

Reactant 2

HCID 69308374(1S)-1-(2-Hydroxyethyl)-3,4-dihydro-1H-2-benzopyran-6-carboxamideHCID 693101721-(2-((Tert-butyldimethylsilyl)oxy)ethyl)-1,3-dihydroisobenzofuran-5-carboxamide

Product 1

HCID 693072701-(2-Hydroxyethyl)-1,3-dihydro-2-benzofuran-5-carboxamide

Procedure

Prepared from 1-[2-(tert-butyldimethylsilanoxy)-ethyl]-1,3-dihydro-2-benzofuran-5-carboxamide, as described for the preparation of (1S)-1-(2-hydroxyethyl)-3,4-dihydro-1H-2-benzopyran-6-carboxamide.

Sources & evidence

ORD record
ord-c8d7a7aa83e84e0abfd8c89df0ffd219
Source dataset
uspto-grants-2008_02
Patent number
US07335660B2

Reaction notes

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