(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazine → 1-(2-[(2R)-4-(6-Fluoro-1-naphthyl)-2-methyl-piperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-carbonitrile

HRID 2056753Notes

Reaction equation

HRID 2056753 reaction equation
CS(O[CH2:6][CH2:7][CH:8]1[C:13]2[CH:14]=[CH:15][C:16]([C:18]#[N:19])=[CH:17][C:12]=2[CH2:11][CH2:10][O:9]1)(=O)=O.[F:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[C:27]([N:31]1[CH2:36][CH2:35][NH:34][C@H:33]([CH3:37])[CH2:32]1)=[CH:26][CH:25]=[CH:24]2>>[F:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[C:27]([N:31]1[CH2:36][CH2:35][N:34]([CH2:6][CH2:7][CH:8]3[C:13]4[CH:14]=[CH:15][C:16]([C:18]#[N:19])=[CH:17][C:12]=4[CH2:11][CH2:10][O:9]3)[C@H:33]([CH3:37])[CH2:32]1)=[CH:26][CH:25]=[CH:24]2

Participants

3

Reactant 2

HCID 69307275(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazineHCID 865960142-(6-Cyano-3,4-dihydro-1H-2-benzopyran-1-yl)ethyl methanesulfonate

Product 1

HCID 693073181-(2-[(2R)-4-(6-Fluoro-1-naphthyl)-2-methyl-piperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-carbonitrile

Procedure

Prepared by condensation of 2-(6-cyano-3,4-dihydro-1H-2-benzopyran-1-yl)ethyl methanesulfonate with (3R)-1-(6-Fluoro-1-naphthyl)-3-methylpiperazine, as described for Example 1b).

Sources & evidence

ORD record
ord-fa4aadf3dc074eefa658b2abcafff9cb
Source dataset
uspto-grants-2008_02
Patent number
US07335660B2

Reaction notes

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