HRID2056765

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69307275

未命名化合物

结构：CS(=O)(=O)OCC[C@@H]1OCCc2cc(N=C(c3ccccc3)c3ccccc3)ccc21

HCID86596020

未命名化合物

PRODUCTS

生成物

结构：C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(N=C(c3ccccc3)c3ccccc3)ccc21

HCID86596019

未命名化合物

PROCEDURE

实验过程

2-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate was coupled with (3R)-1-(6-fluoro-1-naphthyl)-3-methylpiperazine, as described for Example 1b), to yield (1S)-N-(diphenylmethylene)-1-{2-[(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-amine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41a3c3f82f104817a4bb096d52e6b2b2
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07335660B2
来源说明: uspto-grants-2008_02

反应 SMILES

CS(O[CH2:6][CH2:7][C@H:8]1[C:13]2[CH:14]=[CH:15][C:16]([N:18]=[C:19]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:17][C:12]=2[CH2:11][CH2:10][O:9]1)(=O)=O.[F:32][C:33]1[CH:34]=[C:35]2[C:40](=[CH:41][CH:42]=1)[C:39]([N:43]1[CH2:48][CH2:47][NH:46][C@H:45]([CH3:49])[CH2:44]1)=[CH:38][CH:37]=[CH:36]2>>[C:26]1([C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:18][C:16]2[CH:15]=[CH:14][C:13]3[C@H:8]([CH2:7][CH2:6][N:46]4[CH2:47][CH2:48][N:43]([C:39]5[C:40]6[C:35](=[CH:34][C:33]([F:32])=[CH:42][CH:41]=6)[CH:36]=[CH:37][CH:38]=5)[CH2:44][C@H:45]4[CH3:49])[O:9][CH2:10][CH2:11][C:12]=3[CH:17]=2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1