HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazine → (1S)-N-(diphenylmethylene)-1-{2-[(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazine | HCID 69307275 | — |
| Reactant | 2-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate | HCID 86596020 | — |
| Product | (1S)-N-(diphenylmethylene)-1-{2-[(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-amine | HCID 86596019 | — |
Reaction Steps
2-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate was coupled with (3R)-1-(6-fluoro-1-naphthyl)-3-methylpiperazine, as described for Example 1b), to yield (1S)-N-(diphenylmethylene)-1-{2-[(2R)-4-(6-fluoro-1-naphthyl)-2-methylpiperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07335660B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-41a3c3f82f104817a4bb096d52e6b2b2 |
| Source note | uspto-grants-2008_02 |