反应详情

Ethylmagnesium bromide 21.0 ml (an ether solution, 3.0N, 63.1 mmol) and THF 40 ml were charged in a 500 ml reactor purged with nitrogen, 20 ml of a THF solution containing 2-cumyl-4-methylphenol 13.61 g (60.1 mmol) was added dropwise to the reactor at 0° C. in 1 hour and after that, the temperature was gradually raised to a room temperature and the resultant mixture was stirred for 30 minutes at a room temperature, in which toluene 220 ml was added, and then heated to 100° C. and about 50 ml of the mixed solvents of ether and THF were evaporated off to obtain a slightly opaque slurry. After the slurry was cooled to 24° C., p-formaldehyde 4.37 g (145.5 mmol) and triethylamine 12.0 ml (86.0 mmol) were added and the resultant mixture was stirred at 90° C. for 1 hour. After being cooled to a room temperature, the mixture was quenched with 42 ml of 18% hydrochloric acid and an organic layer was concentrated and the obtained liquid was purified by silica gel column chromatography to obtain 3-cumyl-5-methylsalicylaldehyde 14.13 g (yield 92%).

1. custompurged with nitrogen, 20 ml of a THF solution
2. additionwas added dropwise to the reactor at 0° C. in 1 hour
3. additionwas added
4. temperatureheated to 100° C.
5. customabout 50 ml of the mixed solvents of ether and THF were evaporated off
6. customto obtain a slightly opaque slurry
7. temperatureAfter the slurry was cooled to 24° C.
8. temperatureAfter being cooled to a room temperature
9. customthe mixture was quenched with 42 ml of 18% hydrochloric acid
10. concentrationan organic layer was concentrated
11. customthe obtained liquid was purified by silica gel column chromatography