Dimethylamine → HCID 178483442, compound

HRID 2057304Notes

Reaction equation

HRID 2057304 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1.[CH3:39][NH:40][CH3:41]>>[CH3:39][N:40]([CH3:41])[CH2:12][CH2:11][CH2:10][CH2:9][C@H:6]1[CH2:5][CH2:4][C@H:3]([N:2]([CH3:1])[S:33]([C:30]2[CH:31]=[CH:32][C:27]([C:26]([F:38])([F:37])[F:25])=[CH:28][CH:29]=2)(=[O:35])=[O:34])[CH2:8][CH2:7]1

Participants

5

Reactant 4

HCID 674DimethylamineHCID 6422Trifluoroacetic acidHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484800HCID 178484800, compound

Product 1

HCID 178483442HCID 178483442, compound

Procedure

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with dimethlamine to give trans-N-[4-(4-Dimethylamino-butyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 421 (MH+).

Sources & evidence

ORD record
ord-f89d098a880145bf8a5eda877f0d02c5
Source dataset
uspto-grants-2008_02
Patent number
US07335687B2

Reaction notes

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