HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(1-piperidinyl)propyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19936347 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(1-piperidinyl)propyl)- | HCID 3053102 | — |
Reaction Steps
4.9 gm of 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one were after addition of 15 ml of piperidine, refluxed in 150 ml of dioxane for 2 hours. The solvent and excess amine were then distilled off in vacuo, and the residue was recrystallized from n-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04210648 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-6e731a3026914ad49ce0f0400e8c87e3 |
| Source note | uspto-grants-1980_07 |