Piperidine → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(1-piperidinyl)propyl)-

HRID 2057382Notes

Reaction equation

HRID 2057382 reaction equation
[C:1]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)(=[O:4])[CH:2]=[CH2:3].[NH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>O1CCOCC1>[N:21]1([CH2:3][CH2:2][C:1]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 1993634711-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 30531026H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(1-piperidinyl)propyl)-

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4.9 gm of 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one were after addition of 15 ml of piperidine, refluxed in 150 ml of dioxane for 2 hours. The solvent and excess amine were then distilled off in vacuo, and the residue was recrystallized from n-propanol.

Workup

  1. distillationThe solvent and excess amine were then distilled off in vacuo
  2. customthe residue was recrystallized from n-propanol

Sources & evidence

ORD record
ord-6e731a3026914ad49ce0f0400e8c87e3
Source dataset
uspto-grants-1980_07
Patent number
US04210648

Reaction notes

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