11-[3-(Benzylamino)propionyl]-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one → 11-(3-Aminopropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Reaction equation
C([NH:8][CH2:9][CH2:10][C:11]([N:13]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17](=[O:24])[NH:16][C:15]2[CH:25]=[CH:26][CH:27]=[N:28][C:14]1=2)=[O:12])C1C=CC=CC=1>C(O)C.[Pd]>[NH2:8][CH2:9][CH2:10][C:11]([N:13]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17](=[O:24])[NH:16][C:15]2[CH:25]=[CH:26][CH:27]=[N:28][C:14]1=2)=[O:12]Participants
4
Procedure
16.4 gm of 11-[3-(benzylamino)propionyl]-5,11-dihydro-6H-pyrido-[2.3-b][1,4]benzodiazepin-6-one (prepared according to Example 6), together with 3 g of palladium-on-charcoal, were hydrogenated in 300 ml of absolute ethanol for 7 hours at 70° C. and 5 atm. Then the catalyst was filtered off, the alcohol was distilled off, and the residue was purified on a column. After evaporation of the eluate, the residue was recrystallized from ethanol.
Workup
- filtrationThen the catalyst was filtered off
- distillationthe alcohol was distilled off
- customthe residue was purified on a column
- customAfter evaporation of the eluate
- customthe residue was recrystallized from ethanol
Sources & evidence
- ORD record
- ord-0db5ae37453b45eca12ec8deb09ce185
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04210648
Reaction notes
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