11-[3-(Benzylamino)propionyl]-5,11-dihydro-6H-pyrido[2,3-b]-[1,4]benzodiazepin-6-one → 11-(3-Aminopropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Participants

Reaction Steps

16.4 gm of 11-[3-(benzylamino)propionyl]-5,11-dihydro-6H-pyrido-[2.3-b][1,4]benzodiazepin-6-one (prepared according to Example 6), together with 3 g of palladium-on-charcoal, were hydrogenated in 300 ml of absolute ethanol for 7 hours at 70° C. and 5 atm. Then the catalyst was filtered off, the alcohol was distilled off, and the residue was purified on a column. After evaporation of the eluate, the residue was recrystallized from ethanol.

Provenance & Evidence