Sodium Carbonate → HCID 53407179, compound

HRID 2057403Notes

Reaction equation

HRID 2057403 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10](=O)[CH:9]1[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:16][OH:17].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([N:8]1[CH2:12][CH2:11][C:10](=[N:16][OH:17])[CH:9]1[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 124309821-Benzyl-2-methylpyrrolidin-3-one

Product 1

HCID 53407179HCID 53407179, compoundYield 63.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 80 ml of ethanol solution containing 16 g of 1-benzyl-2-methyl-3-pyrrolidone was added 80 ml of aqueous solution containing 13 g of hydroxylamine hydrochloride. After adding 18 g of sodium carbonate to the solution, the mixture was warmed to 35°-40° C. for 30 minutes. The reaction mixture was condensed under reduced pressure to half volume, and the product was extracted twice each time with 80 ml of ether. The extracts were combined and dried over anhydrous magnesium sulfate. The extracts were condensed under reduced pressure to provide 11 g of oily crude 1-benzyl-3-hydroxyimino-2-methylpyrrolidine.

Workup

  1. temperaturethe mixture was warmed to 35°-40° C. for 30 minutes
  2. customcondensed under reduced pressure to half volume
  3. extractionthe product was extracted twice each time with 80 ml of ether
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-d63bffebb80c4b9480e1f034c2ac428c
Source dataset
uspto-grants-1980_07
Patent number
US04210660

Reaction notes

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