Acetic Acid → Hydrochloric Acid

HRID 2057406Notes

Reaction equation

HRID 2057406 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](C)[C:5]2[O:10][CH2:9][CH2:8][C:7](C#N)(O[Si](C)(C)C)[C:6]=2[CH:18]=1.[C:20]([OH:23])(=[O:22])[CH3:21]>>[ClH:1].[Cl:1][C:2]1[CH:18]=[C:6]([CH3:7])[C:5]2[O:10][CH2:9][CH2:8][CH:21]([C:20]([OH:23])=[O:22])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 20332240HCID 20332240, compound

Product 2

HCID 313Hydrochloric AcidHCID 139538016-Chloro-3,4-dihydro-8-methyl-2H-1-benzopyran-4-carboxylic acid

Procedure

Following the procedure of Example 2, 6-chloro-8-methyl-4-cyano-4-trimethylsilyloxy-3,4-dihydro-2H-1-benzopyran (3.1 g.), and stannous chloride dihydrate (12.0 g.) were reacted in glacial acetic acid (25 ml.) and concentrated hydrochloric acid (25 ml.) to form 6-chloro-8-methyl-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid. Recrystallization from hexane yielded 1.67 g. of product, m.p. 95°-96° C.

Sources & evidence

ORD record
ord-8598afdb8e874dab890ff11bff254c72
Source dataset
uspto-grants-1980_07
Patent number
US04210663

Reaction notes

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