Methyl iodide → HCID 23312357, compound

HRID 2057428Notes

Reaction equation

HRID 2057428 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)=[CH:7][C:6]=2[CH:16]=1.[CH3:17][I:18]>CO>[I-:18].[CH3:17][N+:13]1[CH:14]=[CH:15][C:10]([C:8]2[O:9][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:16][C:6]=3[CH:7]=2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 23312351HCID 23312351, compound

Product 1

HCID 23312357HCID 23312357, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

18.5 g (0.087 mole) of 4-(5-fluoro-2-benzofuranyl)-pyridine is dissolved in 170 ml of methanol, and the solution is stirred with 57 ml of methyl iodide for 15 hours at 40°-45°. The solution is thereupon cooled to -10°, and the precipitated salt is filtered off with suction. The filter residue is subsequently washed with 100 ml of cold isopropanol. The 1-methyl-4-(5-fluoro-2-benzofuranyl)-pyridinium-iodide thus obtained can be directly further processed.

Workup

  1. temperatureThe solution is thereupon cooled to -10°
  2. filtrationthe precipitated salt is filtered off with suction
  3. washThe filter residue is subsequently washed with 100 ml of cold isopropanol

Sources & evidence

ORD record
ord-5d6cae9a5b874f409d56a7b8ba0c4dcb
Source dataset
uspto-grants-1980_07
Patent number
US04210655

Reaction notes

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