Methyl iodide → HCID 23312357, compound

Participants

Reaction Steps

18.5 g (0.087 mole) of 4-(5-fluoro-2-benzofuranyl)-pyridine is dissolved in 170 ml of methanol, and the solution is stirred with 57 ml of methyl iodide for 15 hours at 40°-45°. The solution is thereupon cooled to -10°, and the precipitated salt is filtered off with suction. The filter residue is subsequently washed with 100 ml of cold isopropanol. The 1-methyl-4-(5-fluoro-2-benzofuranyl)-pyridinium-iodide thus obtained can be directly further processed.

Provenance & Evidence