HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2057467Generated: November 1, 2026
Diethyl (ethoxymethylene)malonate → Diethyl{[(2-oxo-2H-1-benzopyran-3-yl)amino]methylene}malonate
https://huagongshe.com/reaction/2057467
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 3-Aminocoumarin | HCID 74217 | — |
| Product | Diethyl{[(2-oxo-2H-1-benzopyran-3-yl)amino]methylene}malonate | HCID 12377585 | 89.2% |
Reaction Steps
A mixture of 3-aminocoumarin (30.0 g, 0.186 mole) and diethyl ethoxymethylenemalonate (75.0 g, 0.347 mole) is heated at 120° C. for 4 hours under nitrogen. The reaction mixture is cooled and triturated with hexane. The product is filtered off and washed with hexane. Recrystallization from ethyl acetate gives white crystals (55.0 g, 89%), mp. 134-135.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04210758 |
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| Source dataset | uspto-grants-1980_07 |
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| ORD ID | ord-a87a2ceea0e0465499cbb0b8738a13d5 |
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| Source note | uspto-grants-1980_07 |
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