反应详情

温度

120 °C

A mixture of 3-aminocoumarin (30.0 g, 0.186 mole) and diethyl ethoxymethylenemalonate (75.0 g, 0.347 mole) is heated at 120° C. for 4 hours under nitrogen. The reaction mixture is cooled and triturated with hexane. The product is filtered off and washed with hexane. Recrystallization from ethyl acetate gives white crystals (55.0 g, 89%), mp. 134-135.

1. temperatureThe reaction mixture is cooled
2. customtriturated with hexane
3. filtrationThe product is filtered off
4. washwashed with hexane
5. customRecrystallization from ethyl acetate