Hydrochloric Acid → HCID 178479233, compound

HRID 2057487Notes

Reaction equation

HRID 2057487 reaction equation
C([NH:4][CH2:5][CH2:6][N:7]1[C:11](=[S:12])[NH:10][N:9]=[N:8]1)(=O)C.[ClH:13]>>[ClH:13].[NH2:4][CH2:5][CH2:6][N:7]1[C:11](=[S:12])[NH:10][N:9]=[N:8]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178474870HCID 178474870, compound

Product 1

HCID 178479233HCID 178479233, compoundYield 66.1%

Procedure

A mixture of 21.5 g. (11.4 mmol) of 1-[2-(acetylamino)ethyl]-1,4-dihydro-5H-tetrazole-5-thione in 300 ml. of 6 N hydrochloric acid was heated at reflux for 3.5 hours. The mixture was filtered after cooling to room temperature. The filtrate was concentrated to small volume. The residual liquid was diluted with i-propanol. The solid which precipitated was filtered, washed and dried in vacuo to give 13.7 g. of 1-(2-aminoethyl)-1,4-dihydro-5H-tetrazole-5-thione, hydrochloride (66.1% yield) mp 232°-233.5° C.

Workup

  1. additionA mixture of 21.5 g
  2. temperatureat reflux for 3.5 hours
  3. filtrationThe mixture was filtered
  4. concentrationThe filtrate was concentrated to small volume
  5. additionThe residual liquid was diluted with i-propanol
  6. customThe solid which precipitated
  7. filtrationwas filtered
  8. washwashed
  9. customdried in vacuo
  10. customto give 13.7 g

Sources & evidence

ORD record
ord-2b923a325cf7411580abee5ea67b2ae2
Source dataset
uspto-grants-1980_07
Patent number
US04210587

Reaction notes

Loading…