Acetylacetone → Ethanone, 1-(4-amino-2-methyl-5-(2-methylphenyl)-1H-pyrrol-3-yl)-

HRID 2057521Notes

Reaction equation

HRID 2057521 reaction equation
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:11])[C:3]#[N:4].[C:12]([CH2:15][C:16](=O)[CH3:17])(=[O:14])[CH3:13]>CO>[C:12]([C:15]1[C:3]([NH2:4])=[C:2]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[CH3:11])[NH:1][C:16]=1[CH3:17])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 31261AcetylacetoneHCID 16767703α-Amino-2-methylbenzeneacetonitrile

Product 1

HCID 41888Ethanone, 1-(4-amino-2-methyl-5-(2-methylphenyl)-1H-pyrrol-3-yl)-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Starting from 2-amino-2-(o-tolyl)acetonitrile and acetylacetone, the open-chain intermediate compound is obtained, b.p. 120° C./0.2 mm Hg. The title compound is obtained in a 77% overall yield, m.p. 258° C. (from methanol).

Workup

  1. customthe open-chain intermediate compound is obtained

Sources & evidence

ORD record
ord-96cb8ea122b443bcb3a750f5f38d52a8
Source dataset
uspto-grants-1980_07
Patent number
US04211708

Reaction notes

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