Nitric Acid → 4-Chloro-2-nitrophenol

HRID 2057569Notes

Reaction equation

HRID 2057569 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.O.[N+:10]([O-])([OH:12])=[O:11]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 46844-Chlorophenol

Product 1

HCID 69804-Chloro-2-nitrophenol

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.125 mol (16 g) of 4-chlorophenol, 25 ml of water and 35 ml of acetic acid are introduced into a 125 ml three-necked flask equipped with a stirring system and a thermometer; the mixture is brought to 40° C. and 14.2 ml of nitric acid (d=1.38) are then added drop by drop; the reactants are left in contact for 5 hours. The product is separated by filtration and is crystallized in the minimum of absolute alcohol.

Workup

  1. customequipped with a stirring system
  2. customis brought to 40° C.
  3. customThe product is separated by filtration
  4. customis crystallized in the minimum of absolute alcohol

Sources & evidence

ORD record
ord-0b75820676db45b983b5f89d335c4120
Source dataset
uspto-grants-1980_07
Patent number
US04211776

Reaction notes

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