Hydrochloric Acid → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
Reaction equation
[ClH:1].[CH3:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH2:8][Cl:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14].Cl>>[ClH:9].[ClH:1].[CH3:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH2:8][S:14][CH2:13][CH2:12][NH2:11]Participants
4
Procedure
84 parts of 4-methyl-5-chloromethyl-imidazole hydrochloride, in the form of a fine powder, and 57 parts of cysteamine hydrochloride, also in the form of a fine powder, are mixed intimately and the mixture is heated in a solidstate reactor for 2 hours at 80° and then for 7 hours at 100°; the progress of the reaction can be followed by NMR spectroscopy or from the evolution of hydrogen chloride. 120 parts (98%) of 4-methyl-5-[(2-amino-ethyl)-thiomethyl]-imidazole dihydrochloride are obtained; the substance melts at 186°-189° C., after first sintering at about 181° C. A single recrystallization of the product from ethanol raises the melting point to 193°-195° C.
Workup
- temperaturethe mixture is heated in a solidstate reactor for 2 hours at 80°
- customthe progress of the reaction
Sources & evidence
- ORD record
- ord-8ccdf772c07d41189d4a17a322ca9b84
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04211875
Reaction notes
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