反应详情

To a warm mixture of 7 g. sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate in 100 ml. ethanol is added 4.7 g. ethyl α-tosyloxypropionate. After 17 hours at reflux, the cooled solution is diluted with an equal volume of water and the resultant precipitate is filtered. After washing with cold ethanol and drying, the product is crystallized from acetonitrile to yield 1-(ethoxycarbonyl)ethyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate as colorless crystals.

1. additionTo a warm mixture of 7 g
2. temperatureAfter 17 hours at reflux
3. filtrationthe resultant precipitate is filtered
4. washAfter washing with cold ethanol
5. customdrying
6. customthe product is crystallized from acetonitrile