HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(Ethoxycarbonyl)ethyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 2-[(4-methylbenzenesulfonyl)oxy]propanoate | HCID 562846 | — |
| Reactant | Sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate | HCID 23706318 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Ethoxycarbonyl)ethyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate | HCID 20331323 | — |
Reaction Steps
To a warm mixture of 7 g. sodium 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate in 100 ml. ethanol is added 4.7 g. ethyl α-tosyloxypropionate. After 17 hours at reflux, the cooled solution is diluted with an equal volume of water and the resultant precipitate is filtered. After washing with cold ethanol and drying, the product is crystallized from acetonitrile to yield 1-(ethoxycarbonyl)ethyl 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoate as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04211783 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-f8dd1fe34fb64234a6cf629a03d116fc |
| Source note | uspto-grants-1980_07 |