m-Nitroacetophenone → 2-Bromo-1-(3-nitrophenyl)ethan-1-one

HRID 2057770Notes

Reaction equation

HRID 2057770 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=1)=[O:3].[Br:13]Br>C(Cl)(Cl)Cl>[CH:8]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[CH:5]=[C:4]([C:2]([CH2:1][Br:13])=[O:3])[CH:9]=1

Participants

4

Reactant 2

HCID 8494m-NitroacetophenoneHCID 24408Bromine

Product 1

HCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

60 g. of 3-nitroacetophenone in 250 ml. of chloroform is treated with 58.2 g. of bromine in 50 ml. of chloroform. The solvent is evaporated and the product separated by filtration and recrystallized from benzene to provide α-bromo-3-nitroacetophenone, m.p. 91°-94° C.

Workup

  1. customThe solvent is evaporated
  2. customthe product separated by filtration
  3. customrecrystallized from benzene

Sources & evidence

ORD record
ord-fd438164c85843e8bbe14faa0046be0f
Source dataset
uspto-grants-1980_07
Patent number
US04212865

Reaction notes

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