HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Z-Tyr(tbu)-ome | HCID 7019804 | — |
| Catalyst | Pd barium sulfate | HCID 16218511 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl O-tert-butyl-L-tyrosinate hydrochloride | HCID 6452451 | — |
Reaction Steps
300 g (778 mmoles) of Z-Tyr(But)-OMe (Ann. Chem. 696, 226 (1966)) are dissolved in 1 liter of methanol and hydrogenated catalytically (Pd/BaSO4 catalyst) at pH 4.5, using an auto-burette (about 2 N methanolic HCl being added). After completion of hydrogenation, the catalyst is filtered off and the filtrate is concentrated. The residue is triturated with ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04212796 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-1056f3f79e874fd4a3a7c1eba6adf64f |
| Source note | uspto-grants-1980_07 |