Water → HCID 131711817, compound

HRID 2057850Notes

Reaction equation

HRID 2057850 reaction equation
[NH:1](C(OC(C1C=C(OC)C=C(OC)C=1)(C)C)=O)[C@H:2]([C:24]([NH:26][C@H:27]([C:49]([NH:51][C@H:52]([C:60]([NH:62][C@H:63]([C:70]([OH:72])=[O:71])[CH2:64][O:65]C(C)(C)C)=[O:61])[C@@H:53]([CH3:59])[O:54]C(C)(C)C)=[O:50])[CH2:28][S:29]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:25])[CH2:3][S:4]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O.[F:90][C:91]([F:96])([F:95])[C:92]([OH:94])=[O:93]>C(S)C>[NH2:1][C@H:2]([C:24]([NH:26][C@H:27]([C:49]([NH:51][C@H:52]([C:60]([NH:62][C@H:63]([C:70]([OH:72])=[O:71])[CH2:64][OH:65])=[O:61])[C@@H:53]([CH3:59])[OH:54])=[O:50])[CH2:28][SH:29])=[O:25])[CH2:3][SH:4].[F:90][C:91]([C:92]([OH:94])=[O:93])([F:96])[F:95]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 131711819HCID 131711819, compound

Product 1

HCID 131711817HCID 131711817, compound

Reagents, catalysts & solvents 1

HCID 6343EthanethiolSolvent

Procedure

615.8 mg (0.5 mmole) of Ddz-Cys(Trt)-Cys(Trt)-Thr(But)-Ser(But)-OH are dissolved in a mixture of 2.5 ml of ethylmercaptan and 2.5 ml of trifluoroacetic acid. The reaction mixture is stirred for 4 hours at room temperature and is then poured into 50 ml of water. The aqueous phase is extracted three times with ether and is then freeze-dried.

Workup

  1. extractionThe aqueous phase is extracted three times with ether
  2. customis then freeze-dried

Sources & evidence

ORD record
ord-9ecadd0965694ebaad7fccfffb3e3318
Source dataset
uspto-grants-1980_07
Patent number
US04212796

Reaction notes

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