Hydrochloric Acid → HCID 86737098, compound

HRID 2057869Notes

Reaction equation

HRID 2057869 reaction equation
ClC1C=CC(C([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:10][C:9]=2[CH3:18])=O)=CC=1.[Na].ClC1C=CC(C(C2N(C)C(CC#N)=CC=2C)=O)=CC=1.C([SH:43])C.Cl>>[CH3:13][N:12]1[CH:8]=[C:9]([CH3:18])[CH:10]=[CH:11]1.[S:43]1[CH:8]=[CH:9][CH:10]=[C:11]1[CH2:14][C:15]([O-:17])=[O:16]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6343EthanethiolHCID 1853102264092-48-4HCID 20329086HCID 20329086, compound

Product 1

HCID 86737098HCID 86737098, compound

Procedure

A process of preparing sodium 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid which comprises reacting 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetonitrile with ethyl mercaptan in the presence of hydrogen chloride in an anhydrous aprotic organic solvent under an inert atmosphere at or below 10° C. to yield ethyl 5-(p-chlorobenozyl)- 1,4-dimethylpyrrole-2-thiolacetate and then hydrolyzing said thiolacetate by treatment with aqueous sodium hydroxide.

Workup

  1. custombelow 10° C.

Sources & evidence

ORD record
ord-08599775d9814dceace8464bf5435606
Source dataset
uspto-grants-1980_07
Patent number
US04213905

Reaction notes

Loading…