反应详情

A process of preparing sodium 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid which comprises reacting 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetonitrile with ethyl mercaptan in the presence of hydrogen chloride in an anhydrous aprotic organic solvent under an inert atmosphere at or below 10° C. to yield ethyl 5-(p-chlorobenozyl)- 1,4-dimethylpyrrole-2-thiolacetate and then hydrolyzing said thiolacetate by treatment with aqueous sodium hydroxide.

1. custombelow 10° C.