Triethylamine → 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Reaction equation
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[N:21][C:7]1=2)=[O:5].C(N(CC)CC)C>O1CCOCC1>[C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[N:21][C:7]1=2)(=[O:5])[CH:3]=[CH2:2]Participants
4
Procedure
A solution of 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one in dioxane was refluxed for one hour in the presence of an excess of triethylamine to obtain a good yield of 11-(acryloyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which after crystallization from acetonitrile melted at 235° C. with decomposition.
Sources & evidence
- ORD record
- ord-30bfca3eee384c2fa1f7f11dea0c9767
- Source dataset
- uspto-grants-1980_07
- Patent number
- US04213985
Reaction notes
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