1-Benzylpiperazine → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(4-(phenylmethyl)-1-piperazinyl)propyl)-

HRID 2057900노트

반응식

HRID 2057900 반응식
[C:1]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)(=[O:4])[CH:2]=[CH2:3].[CH2:21]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O1CCOCC1>[CH2:21]([N:28]1[CH2:33][CH2:32][N:31]([CH2:3][CH2:2][C:1]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:30][CH2:29]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

참가 물질

4

반응물 2

HCID 759941-BenzylpiperazineHCID 1993634711-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

생성물 1

HCID 30532046H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(4-(phenylmethyl)-1-piperazinyl)propyl)-수율 54%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2.65 g of the product of Step A and 5.4 g of 1-benzyl-piperazine in 90 ml of absolute dioxane was refluxed for 2 hours and was then evaporated to dryness under reduced pressure. The residue was crystallized from isopropanol to obtain a 54% yield of 5,11-dihydro-11-[3-(4-benzyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 205°-207° C.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customwas then evaporated to dryness under reduced pressure
  3. customThe residue was crystallized from isopropanol

출처 및 근거

ORD 기록
ord-cf3bd1dd774a46e89b2487abe6a36010
출처 데이터셋
uspto-grants-1980_07
특허 번호
US04213985

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