反应详情

A mixture of 2.65 g of the product of Step A and 5.4 g of 1-benzyl-piperazine in 90 ml of absolute dioxane was refluxed for 2 hours and was then evaporated to dryness under reduced pressure. The residue was crystallized from isopropanol to obtain a 54% yield of 5,11-dihydro-11-[3-(4-benzyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 205°-207° C.

1. temperaturewas refluxed for 2 hours
2. customwas then evaporated to dryness under reduced pressure
3. customThe residue was crystallized from isopropanol