HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(4-(phenylmethyl)-1-piperazinyl)propyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 11-acryloyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19936347 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-(1-oxo-3-(4-(phenylmethyl)-1-piperazinyl)propyl)- | HCID 3053204 | 54% |
Reaction Steps
A mixture of 2.65 g of the product of Step A and 5.4 g of 1-benzyl-piperazine in 90 ml of absolute dioxane was refluxed for 2 hours and was then evaporated to dryness under reduced pressure. The residue was crystallized from isopropanol to obtain a 54% yield of 5,11-dihydro-11-[3-(4-benzyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 205°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213985 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-cf3bd1dd774a46e89b2487abe6a36010 |
| Source note | uspto-grants-1980_07 |