2-Chloropropionyl chloride → HCID 20256761, compound

HRID 2057901Notes

Reaction equation

HRID 2057901 reaction equation
[Cl:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].C[N:8]1[C:14](=[O:15])[C:13]2[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=2[NH:11][C:10]2[N:20]=[CH:21][CH:22]=[CH:23][C:9]1=2>O1CCOCC1>[Cl:1][CH:2]([CH3:6])[C:3]([N:11]1[C:12]2[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=2[C:14](=[O:15])[NH:8][C:9]2[CH:23]=[CH:22][CH:21]=[N:20][C:10]1=2)=[O:4]

Participants

4

Reactant 2

HCID 1110192-Chloropropionyl chlorideHCID 12184078HCID 12184078, compound

Product 1

HCID 20256761HCID 20256761, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-chloropropionyl chloride and 5-methyl-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one in dioxane was reacted to obtain 11-(2-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which after crystallization from acetonitrile melted at 210°-212° C.

Sources & evidence

ORD record
ord-e61895ef6c2a4c94a4ffb6d90c8ad757
Source dataset
uspto-grants-1980_07
Patent number
US04213985

Reaction notes

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