1-Methylpiperazine → HCID 53775980, compound

HRID 2057908Notes

Reaction equation

Cl[CH:2]([CH3:21])[C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([CH:2]([CH3:21])[C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 20256761HCID 20256761, compound

Product 1

HCID 53775980HCID 53775980, compoundYield 49%

Procedure

Using the procedure of Example 5, the product of Step A was reacted with 1-methyl-piperazine to obtain a 49% yield of 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)-propionyl]-6-H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which melted at 223°-224° C. after crystallization from ethyl acetate.

Sources & evidence

ORD record: ord-a3e0e8d67e6548fcbd9c8087c2ca8b0c
Source dataset: uspto-grants-1980_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04213985

Reaction notes

Loading…