HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → HCID 14054138, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 13810571 | — |
| Product | HCID 14054138 | HCID 14054138 | 51% |
Reaction Steps
Using the procedure of Example 2, 11-(3-chloropropionyl)-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one and 1-methyl-piperazine were reacted to obtain a 51% yield of 5,11-dihydro-11-[3-(4-methyl-1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one which melted at 232°-233° C. after crystallization from an ethyl acetate-ethanol mixture. The dihydrochloride thereof melted at 235° C. after crystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04213985 |
| Source dataset | uspto-grants-1980_07 |
| ORD ID | ord-c72b73484c1345fcb53ae600766a0388 |
| Source note | uspto-grants-1980_07 |